Open a new tmux session with 2 extra windows all named (-n) and start an application in each:

tmux new-session -n ssh \; \
send-keys 'ssh root@10.10.10.10' C-m \; \
new-window -n profile \; \
send-keys 'vi .profile' C-m \; \
new-window -n etc \; \
send-keys 'ls -l /etc' C-m \; \
attach

Sources:

• Stack Overflow - How to set up tmux so that it starts up with specified windows opened?
• Stack Overflow - How to start tmux with several windows in different directories?

Store the below in your ~/.tmux.conf:

# Override the default-client-command to 'attach' so it attaches to the session we are about to start (instead of a session after that).
# default-client-command does not exist in all tmux version. It works on OpenBSD, but not on Devuan 6.0.0
set-option -g default-client-command attach
# Don't kill windows on exit of the command that's running in them.
# Then you can use C-b-: and :respawn-window to restart the window with the command.
set-option -g remain-on-exit on
new-session -s DEFAULT top
new-window radeontop
new-window
new-window mc
new-window