Roland Sound Canvas
SC-55

Sound Programming - Synths -> Roland -> Roland SC-88
Sound Programming - Synths -> Roland -> Roland SC-88Pro

Can be connected to modern PC's with something like Roland UM-ONE mk2 USB MIDI Interface which should be compatible with DOSBox and ScummVM.
Source:YouTube - Roland Sound Canvas SC-55: 90s MIDI Excellence.

Using the computer port on an SC-55mk2 or SC-88 with DOS (games) may require SoftMPU a DOS TSR that emulates an ‘intelligent mode’ hardware MPU-401 interface.

BOB'S MIDI INFORMATION - Roland Supplemental Notes

88 Edit is a system exclusive message generator for the Roland Sound Canvas SC-88 and other sound modules bearing the GS logo. By Great White North Technologies.

By LGR:

• YouTube - Roland SC-55ST: $400 MIDI Music Powerhouse from 1993
• YouTube - Roland Sound Canvas SC-55: 90s MIDI Excellence

Predecessor (of sorts) the MT-32:

• YouTube - LGR - Roland MT-32: Retro PC MIDI Music Revisited by LGR.
• YouTube - The Best Sound for MS-DOS Games - Roland MT-32 by 8-Bit Keys.